1: sulfuric acid / 1,2,3,4-tetrahydro-naphthalene / 1 h / 150 - 210 °C / |Inert atmosphere
2: trichlorophosphate / water / 0.5 h / |Reflux; |Inert atmosphere
3: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C / |Inert atmosphere
4: triphenylphosphine / tetrahydrofuran / 0.33 h / 20 °C / |Inert atmosphere
5: pyridine / 1 h / 60 °C / |Inert atmosphere
6: ammonium formate; 5 palladium on charcoal / methanol / 20 h / 20 °C / |Inert atmosphere
7: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C / |Inert atmosphere
8: dichloromethane
View Scheme
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
MgCl2*6H2O; toluene-4-sulfonic acid in methanol
10 h; Reflux;
参考文献
Francisco, Acacio I.; Vargas, Maria D.; Carneiro, J. Walkimar de M.; Lanznaster, Mauricio; Torres, Jose C.; Camara, Celso A.; Pinto, Angelo C.
Journal of Molecular Structure, 2008 , vol. 891, # 1-3 p. 228 - 232
