1.1: hydrogenchloride; sodium nitrite / water / 0.17 h / -5 °C
1.2: 1.75 h / -5 - 0 °C
2.1: tetrahydrofuran / 0.5 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Rennison, David; Conole, Daniel; Tingle, Malcolm D.; Yang, Junpeng; Eason, Charles T.; Brimble, Margaret A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6629 - 6635
1: 4-nitro-aniline With hydrogenchloride; sodium nitrite in water
T=5°C;
2: Aniline mustard in ethanol; water
T=5 - 10°C; 3 h;
3: With sodium hydroxide in ethanol; water
参考文献
Kolli, Balakrishna; Mishra, Sarada P.; Joshi; Raj Mohan; Dhami; Samui
Journal of Polymer Science, Part A: Polymer Chemistry, 2012 , vol. 50, # 8 p. 1572 - 1578
