反应条件
1: 1.) PCl3, pyridine / 2.) pyridine, 70-80 degC, 3 h, room temperature, 10 h
2: 25percent HBr, acetic acid
3: 58 percent / 1-hydroxybenzotriazole, Et3N, N,N'-dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature
4: 5.4N HCl / dioxane
5: 53 percent / 1-hydroxybenzotriazole, Et3N, N,N'-dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature
View Scheme
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 12 p. 5301 - 5309