1: pyridine / 12 h / 0 - 20 °C 2: DIPEA / Pd(PPh3)2Cl2; CuI / dimethylformamide / 48 h / 45 °C 3: aq. NaOH / diethyl ether; methanol / 18 h 4: CuSO4; sodium ascorbate; KHCO3 / 2-methyl-propan-2-ol; H2O / 24 h / 50 °C 5: aq. NaOH / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Soellner, Matthew B.; Rawls, Katherine A.; Grundner, Christoph; Alber, Tom; Ellman, Jonathan A.
Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9613 - 9615