potassium hydroxide; Ru(cymene2)Cl2; L-proline in isopropyl alcohol
dependence of yield and enantiomeric excess on structure of the substrate; Product distribution;
1: NaH / dioxane / Heating
2: p-TsOH / toluene / 80 °C
3: diphenyl ether / 200 °C
View Scheme
参考文献
Vu, An T.; Cohn, Stephen T.; Manas, Eric S.; Harris, Heather A.; Mewshaw, Richard E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4520 - 4525
1: 1-(4-methoxyphenyl)ethanone With (hydroxy(tosyloxy)iodo)benzene in acetonitrile
0.666667 h; Heating;
2: benzenesulphinic acid sodium salt in water; acetonitrile
2 h; Heating;
