反应条件
1: 89 percent / 16 h / Heating
2: 1) n-Butyllithium / 1) THF, ice bath , 6 h, 2) THF, room temperature, 4 h
3: 85 percent / acetonitrile / 12 h / Heating
4: 1) NaBH4, 2) 2N-HCl / 1) ethanol, 0-5 deg C, 2 h, 2) methanol, heating, 30 min
5: 1) n-Butyllithium / 1) THF, a) -78 deg C, b) room temperature, 1.5 h, 2) THF, a) -78 deg C, 0.5 h, b) room temperature, 16 h
View Scheme
参考文献
Mohan, Raju; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1238 - 1246
