反应条件
1: 3 h / 100 °C
2: 1.) 4-(hydroxymethyl)phenoxyacetic acid, HOBt, DIPCDI, (aminomethyl)polystyrene, 2.) CBr4, PPh3, 3.) <(CH3)3SiNK, 4.) NaOMe, 5.) TFA / 1.) CH2Cl2, DMF, overnight, 2.) CH2Cl2, 0 deg C, 3.) DMF, overnight, 4.) DMF, overnight, 5.) H2O, 2 h
View Scheme
参考文献
Howard Adams; Cook, Ronald M.; Hudson, Derek; Jammalamadaka, Vasu; Lyttle, Matthew H.; Songster, Michael F.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3706 - 3716
