1-(氯甲基)-4-硝基苯合成路线 （共 349 条）
反应条件
1: 74 percent / Na, EtOH / 12 h / Heating 2: 1.) H2, 2.) HCl / 1.) 10percent Pd/C / 1.) ethanol, 8 h, reflux 3: 1.) NaNO2, 37percent HCl, 2.) H3PO4 / 1.) MeOH, 3 h, reflux, water View Scheme
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
sodium hydroxide; 1-phenylalkyl isocyanide (R=C2H5); tetrabutylammomium bromide in benzene T=36°C; 4.5 h;
参考文献
Jawdosiuk, Mikolaj; Uminski, Maciej; Kmiotek-Skarzynska, Irena; Makasza, Mieczyslaw
Polish Journal of Chemistry, 1981 , vol. 55, # 6 p. 1309 - 1320
反应条件
sodium methylate in ethylene glycol dimethyl ether 12 h;
参考文献
Chemische Berichte, , vol. 122, p. 493 - 498
反应条件
(iPrO)2PONa in tetrahydrofuran 3 h; Ambient temperature;
参考文献
Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 91, # 1-4 p. 153 - 164
反应条件
methanol; sodium methylate
参考文献
Bischoff
Chemische Berichte, 1907 , vol. 40, p. 3135
参考文献
Kleucker
Chemische Berichte, 1922 , vol. 55, p. 1648
反应条件
sodium ethanolate 1.) EtOH, reflux, 2 h, 2.) reflux, 0.5 h; Multistep reaction. Yields of byproduct given;
参考文献
Dorgan, Roderick J.J.; Parrick, John; Hardy, Christopher R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 938 - 942
反应条件
sodium hydride 1.) THF, 2.) THF, RT, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Witt, Dariusz; Rachon, Janusz
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 91, # 1-4 p. 153 - 164
参考文献
Barrow; Griffiths
Journal of the Chemical Society, 1921 , vol. 119, p. 216
参考文献
Romeo
Gazzetta Chimica Italiana, 1905 , vol. 35 I, p. 111
