1-(氯甲基)-4-硝基苯合成路线 （共 349 条）
反应条件
sodium hydroxide; tetrabutylammomium bromide in benzene
T=34°C; 4 h;
参考文献
Jawdosiuk, Mikolaj; Uminski, Maciej
Journal of the Chemical Society, Chemical Communications, 1982 , # 17 p. 979 - 980
反应条件
1: butanone; sodium iodide
2: aqueous Na2CO3
3: acetic acid anhydride
4: mit Hilfe von Cinchonidin
5: hydrogen chloride
View Scheme
参考文献
Bergel et al.
Journal of the Chemical Society, 1955 , p. 1229
Org. Synth. Isotopes, 1958 , p. 303
反应条件
tetrakis(dimethylamino)ethylene in N,N-dimethyl-formamide
T=-20 - 70°C; 3 h; Inert atmosphere;
参考文献
Since, Marc; Terme, Thierry; Vanelle, Patrice
Tetrahedron, 2009 , vol. 65, # 31 p. 6128 - 6134
反应条件
2: Et3N / acetone / 2 h / Heating
View Scheme
参考文献
Lipka,P.; Wobig,D.
Liebigs Annalen der Chemie, 1979 , # 6 p. 757 - 760
反应条件
(i) acetone, (ii) Et3N; Multistep reaction;
参考文献
Lipka,P.; Wobig,D.
Liebigs Annalen der Chemie, 1979 , # 6 p. 757 - 760
参考文献
Curtius
Journal fuer Praktische Chemie (Leipzig), 1930 , vol. <2> 125, p. 211,284
参考文献
Lellmann; Schleich
Chemische Berichte, 1887 , vol. 20, p. 441
Show Details
Reissert
Chemische Berichte, 1894 , vol. 27, p. 2248
反应条件
1: 75 percent / K2CO3 / acetone / 46 h / Heating
2: 70 percent / Fe, 10percent FeCl3 / ethanol; H2O / 15 h / Heating
3: 46 percent / 1M H2SO4, NaNO2 / H2O / 0.83 h / 0 - 85 °C
View Scheme
参考文献
Biagi; Dell'Omodarme; Ferretti; Giorgi; Livi; Scartoni
Farmaco, 1992 , vol. 47, # 3 p. 335 - 344
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol; water
T=65°C; 3 h;
参考文献
DECODE GENETICS EHF
Patent: US2009/130076 A1, 2009 ;
Location in patent: Page/Page column 35; 36 ;
US 20090130076 A1
参考文献
Clerici; Pocar; Guido; Loche; Perlini; Brufani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 931 - 936
