1-(氯甲基)-4-硝基苯合成路线 （共 349 条）
反应条件
potassium hydroxide in methanol
2 h; Ambient temperature;
参考文献
Nemeryuk, Michal P.; Sedov, Andrej L.; Safonova, Tamara S.; Cerny, Antonin; Krepelka, Jiri
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 1 p. 215 - 233
反应条件
1: 1.) KOH / 1.) EtOH, 20 min, 2.) EtOH, 30 min
2: 1.) Na2WO4, 2.) H2O2 / 1.) EtOH, H2O, 0 deg C, 3.) EtOH, H2O, reflux, 45 min
View Scheme
参考文献
Claesen, C. A. A.; Segers, R. P. A. M.; Tesser, G. I.
Recueil des Travaux Chimiques des Pays-Bas, 1985 , vol. 104, p. 119 - 122
反应条件
1: sodium methylate; methanol
2: aq.-ethanolic HCl
View Scheme
参考文献
Eckstein; Urbanski
Roczniki Chemii, 1956 , vol. 30, p. 1175,1178
Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1955 , vol. <III> 3, p. 433,434
反应条件
1: 3-bromo-5-trimethysilyltoluene With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: 4-nitrobenzyl chloride in tetrahydrofuran
T=-78 - 20°C; 16 h;
参考文献
KARO BIO AB
Patent: WO2007/3419 A1, 2007 ;
Location in patent: Page/Page column 56; 57 ;
WO 2007/003419 A1
反应条件
potassium tert-butylate in dichloromethane
参考文献
Chhaly, Leang; Pritzkow, Wilhelm
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 6 p. 558 - 560
参考文献
Chernobrovin, N. I.; Kozhevnikov, Yu. V.; Zalesov, V. S.; Gradel', I. I.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 7 p. 485 - 488
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 7 p. 830 - 833
反应条件
iron(III) chloride
T=130 - 140°C; 0.333333 h; other temperatures, times and catalysts; Product distribution;
参考文献
Tadzhimukhamedov, Kh. S.; Abdurasuleva, A. R.; Akhmedov, K. N.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, # 5 p. 944 - 946
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 5 p. 1037 - 1040
反应条件
in N,N-dimethyl-formamide
T=120°C; 0.5 h;
参考文献
Su, Tsann-Long; Chou, Ting-Chao
Patent: US2008/176889 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
potassium carbonate in dimethyl sulfoxide; acetonitrile
1.25 h; Irradiation;
参考文献
Gharbaoui, Tawfik; Benhida, Rachid; Chastanet, Jacqueline; Lechevallier, Andre; Maillos, Philippe; Beugelmans, Rene
Bulletin de la Societe Chimique de France, 1994 , vol. 131, p. 561 - 574
反应条件
water; potassium carbonate
参考文献
Pawlewski
Chemische Berichte, 1904 , vol. 37, p. 592
