1-(氯甲基)-4-硝基苯合成路线 （共 349 条）
反应条件
1: 52 percent / triethylamine / CH2Cl2 / 12 h / 0 °C 2: 26 percent / potassium tert-butoxide, 1-pentanethiol / dimethylsulfoxide; pyridine / 4 h / 120 °C View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 28, # 1.1 p. 35 - 41
Zhurnal Organicheskoi Khimii, , vol. 28, # 1 p. 43 - 50
参考文献
Snyder; Demuth
Journal of the American Chemical Society, 1956 , vol. 78, p. 1981,1983
反应条件
1: 99 percent / tetrahydrofuran / 20 °C 2: 1.9 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h / 20 °C View Scheme
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
反应条件
potassium carbonate in ethanol 1 h; Microwave irradiation;
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Wu, Shan; Jiang, Yi; Jin, Xin; Guo, Hai-Ming
Chemistry - An Asian Journal, 2012 , vol. 7, # 1 p. 45 - 49
反应条件
1: ethanol 2: concentrated aqueous HBr View Scheme
参考文献
Schloegl et al.
Monatshefte fuer Chemie, 1952 , vol. 83, p. 845,861
反应条件
hydrogenchloride; potassium carbonate; tetrabutylammomium bromide 1.) acetonitrile, 1 h, reflux, 2.) ether, 3 h, 3.) reflux, 6 h; Yield given. Multistep reaction;
参考文献
O'Donnell, Martin J.; Wojciechowski, Krzysztof; Ghosez, Leon; Navarro, Mirtha; Sainte, Francy; Antoine, Jean-Pierre
Synthesis, 1984 , # 4 p. 313 - 315
反应条件
tetrakis(dimethylamino)ethylene in N,N-dimethyl-formamide T=-20 - 20°C; 3 h;
参考文献
Giuglio-Tonolo, Gamal; Terme, Thierry; Medebielle, Maurice; Vanelle, Patrice
Tetrahedron Letters, 2003 , vol. 44, # 34 p. 6433 - 6435
反应条件
sodium ethanolate in ethanol; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche
Patent: US3830840US3931268 , 19741976 ;
Chem.Abstr., 1976 , vol. 84, # 150385
反应条件
potassium carbonate in acetonitrile 58 h; Irradiation;
参考文献
Beugelmans, Rene; Lechevalier, Andre
Tetrahedron Letters, 1986 , vol. 27, # 51 p. 6209 - 6212
反应条件
1: 1H-indole-3-carbaldehyde With sodium hydride in dimethyl sulfoxide; mineral oil T=20°C; 1 h; 2: 4-nitrobenzyl chloride in dimethyl sulfoxide; mineral oil T=20°C;
参考文献
Wu, Shuhong; Wang, Li; Guo, Wei; Liu, Xiaoying; Liu, Jinsong; Wei, Xiaoli; Fang, Bingliang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2668 - 2679
