1: 2,3-dimethoxytetrahydrofuran With hydrogenchloride in water T=20°C; 0.333333 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With sodium acetate in water T=0 - 50°C; 3.08333 h; 3: With sodium hydrogencarbonate in diethyl ether; water pH=7;
1: With sodium hydroxide; sodium dihydrogenphosphate pH=4.5; 2: With hydrogenchloride T=85°C; pH=3; 2 h; 3: With sodium hydroxide; di-tert-butyl dicarbonate more than 3 stages;
参考文献
THERAVANCE, INC.
Patent: US2006/100236 A1, 2006 ;
Location in patent: Page/Page column 20 ;
US 20060100236 A1
1: N-chloro-succinimide / acetonitrile / 3 h / 20 °C 2: 2,2'-azo-bisisobutyronitrile; tert.-butylhydroperoxide / acetonitrile; water / 24 h / 80 °C View Scheme
