反应条件
1: p-TsOH*H2O / toluene / 4 h / Heating
2: 69 percent / nitromethane / 48 h / Ambient temperature; further solvents
3: 80 percent / (n-Bu)4NBr, aq. NaOH / 0.5 h / Heating
4: LAH*bis-THF / tetrahydrofuran / Ambient temperature; further reagents and solvents
5: 83 percent / BF3*Et2O / CH2Cl2 / 1 h / 0 °C
6: 85 percent / KOH / 2-methyl-propan-2-ol / 1 h / Heating
View Scheme
参考文献
Maguire, Anita R.; Plunkett, Stephen J.; Papot, Sebastien; Clynes, Martin; O'Connor, Robert; Touhey, Samantha
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 745 - 762
