1: Tributyl-((2S,6S)-6-isopropyl-2-phenyl-tetrahydro-pyran-2-yloxymethyl)-stannane With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: benzaldehyde in tetrahydrofuran; hexane 0.5 h; Further stages.;
tri-tert-butyl phosphine; bis(1,5-cyclooctadiene)nickel (0) in tetrahydrofuran; water T=20°C; 20 h; Product distribution; Further Variations:Solventsamount of water; with additive;
参考文献
Hirano, Koji; Yorimitsu, Hideki; Oshima, Koichiro
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 12-13 p. 1543 - 1546
catalyst: (-)-3-exo-(dimethylamino)isoborneol in toluene toluene-soln. of catalyst added Bu2Zn at 30°C; after 15 min added Et2Zn; mixt. stirred for 10 min and cooled to 0°C; added benzaldehyde; mixt. stirred at 0°C for 6 h; quenched (water); analyzed by HPLC;
参考文献
Journal of the American Chemical Society, , vol. 111, # 11 p. 4028 - 4036
