1.1: diethyl ether; tetrahydrofuran / 0 °C / Reflux
2.1: formic acid; dihydrogen peroxide / water / 4 h / 20 °C
3.1: sodium hydride / ethylene glycol dimethyl ether / 1 h / 0 °C
3.2: 2 h / Reflux
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
1: With NiII chloride hexahydrate in tetrahydrofuran; toluene
T=20°C; 1 h; Inert atmosphereSchlenk technique;
2: With water in tetrahydrofuran; toluene
Inert atmosphereSchlenk technique; stereoselective reaction;
参考文献
Xue, Fei; Zhao, Jin; Hor, T. S. Andy
Chemical Communications, 2013 , vol. 49, # 86 p. 10121 - 10123
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758