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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
溴化苯基镁
合成路线
(共 1496 条)
100-58-3
溴化苯基镁
+
4392-24-9
肉桂基溴
→
反应条件
3542-14-1
+
3412-44-0
反应条件
n-butyllithium; (4R),(5R)-N,N'-dimethyl-4,5-diphenyl-4,5-dihydroimidazolinium iodide; copper(l) chloride in hexane; dichloromethane T=25°C; 1 h; Inert atmosphere; Overall yield = 99 percentSpectr.; regioselective reaction;
参考文献
Ando, Shin; Matsunaga, Hirofumi; Ishizuka, Tadao
Tetrahedron, 2013 , vol. 69, # 6 p. 1687 - 1693
21087-29-6
肉桂基氯
+
100-58-3
溴化苯基镁
→
反应条件
3542-14-1
+
3412-44-0
+
58463-02-8
+
74120-63-1
反应条件
in diethyl ether T=30°C; 1 h;
参考文献
Muraoka, Kiyoshige; Nojima, Masatomo; Kusabayashi, Shigekazu; Nagase, Shigeru
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 761 - 768
7681-65-4
碘化亚铜
+
100-58-3
溴化苯基镁
→
反应条件
3220-49-3
反应条件
in tetrahydrofuran T=-15°C; Inert atmosphere;
参考文献
Pekel, Oezgen Oemuer; Erdik, Ender
Journal of Organometallic Chemistry, 2014 , vol. 751, p. 644 - 653
100-58-3
溴化苯基镁
+
7787-70-4
→
反应条件
3220-49-3
反应条件
in tetrahydrofuran CuBr suspended in THF at 0°C, a soln. of C6H5MgBr dropped at 0°C, stirred for 2 h at room temp.; sepd., washed (THF);
参考文献
Fischer, Reinald; Goerls, Helmar; Westerhausen, Matthias
Organometallics, 2007 , vol. 26, # 14 p. 3269 - 3271
40175-06-2
+
100-58-3
溴化苯基镁
→
反应条件
34591-70-3
反应条件
1: in diethyl ether T=0°C; 2 h; 2: With water; ammonium chloride in diethyl ether
参考文献
Kinney, William A.; Luci, Diane K.; Maryanoff, Bruce E.
Patent: US2005/26917 A1, 2005 ;
Location in patent: Page/Page column 15-16 ;
4701-17-1
+
100-58-3
溴化苯基镁
→
反应条件
19163-21-4
+
32364-72-0
+
92-52-4
反应条件
1: phenyl-magnesium bromide With bismuth(III) chloride 2: 5-Bromothiophene-2-carboxaldehyde With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere; chemoselective reaction;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
4706-43-8
+
100-58-3
溴化苯基镁
+
17082-12-1
→
反应条件
32812-31-0
反应条件
n-butyllithium 1.) THF, -78 deg C, 10 min, 2.) THF, from -78 deg C to RT, overnight; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Verin, Sergei V.; Yang, Baozhen
Organic Preparations and Procedures International, 1996 , vol. 28, # 1 p. 97 - 101
100-58-3
溴化苯基镁
+
142570-56-7
→
反应条件
333387-97-6
反应条件
in tetrahydrofuran T=0 - 20°C; Grignard reaction;
参考文献
Rossi, Matteo; Bang, Jeong-kyu; Mazur, Sharlyn; Iera, Jaclyn A.; Phillips, Darren C.; Zambetti, Gerard P.; Appella, Daniel H.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2429 - 2434
100-58-3
溴化苯基镁
→
反应条件
34422-60-1
反应条件
1: not given 2: ammonia 3: not given 5: ammonia 6: ammonia View Scheme
参考文献
Gmelin Handbook: Ge: MVol., 20, page 53 - 57
100-58-3
溴化苯基镁
→
反应条件
35664-70-1
反应条件
1: CuI*LiCl 2: 1.) CAN, CaCO3, 2.) DDQ, p-TsOH / 1.) MeOH, 20 deg C, 2.) C6H6, reflux, 3.0 h View Scheme
参考文献
Belli Paolobelli, Anna; Ruzziconi, Renzo; Lupattelli, Paolo; Scafato, Patrizia; Spezzacatena, Caterina
Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 3364 - 3368
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