1: With AlCl3, aluminium chloride in dichloromethane
T=0 - 20°C; Friedel Crafts Acylation; 12 h;
2: With hydrogenchloride; water in dichloromethane
T=0°C;
1: methyl-phenyl-thioether With n-butyllithium in tetrahydrofuran
T=20°C; 0.25 h;
2: With lithium chloride in tetrahydrofuran
T=0°C; 0.25 h;
3: 1-chloro-2-chloromethyl-2-propene in tetrahydrofuran
T=0°C; 2 h;
参考文献
Alonso, Francisco; Melendez, Jaisiel; Soler, Tatiana; Yus, Miguel
Tetrahedron, 2006 , vol. 62, # 10 p. 2264 - 2277
Penning, Thomas D.; Kramer, Steven W.; Lee, Len F.; Collins, Paul W.; Koboldt, Carol M.; Seibert, Karen; Veenhuizen, Amy W.; Zhang, Yan Y.; Isakson, Peter C.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 16 p. 2121 - 2124
