1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran Inert atmosphere; 2: 2-pyridine carbonitrile in tetrahydrofuran T=0°C; Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether 0.5 h; Inert atmosphere;
1: With trifluorormethanesulfonic acid in dichloromethane T=60 - 80°C; Houben-Housch synthesis; Inert atmosphere; 2: With water in dichloromethane Houben-Housch synthesis; Inert atmosphereCooling with ice; 3: With sodium hydroxide in water Inert atmosphere;
参考文献
Raja, Erum K.; Klumpp, Douglas A.
Tetrahedron, 2011 , vol. 67, # 25 p. 4494 - 4497
diethyl ether und Behandeln des Reaktionsgemisches mit wss.Salzsaeure;
参考文献
de Jonge et al.
Recueil des Travaux Chimiques des Pays-Bas, 1951 , vol. 70, p. 989,996
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Glover; Jones
Journal of the Chemical Society, 1959 , p. 1686,1689
