1: in diethyl ether
T=-15 - 20°C; 4 h; Inert atmosphere;
2: With hydrogenchloride in diethyl ether; water
T=0°C; 0.25 h;
参考文献
INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH; CUCONATI, Andrea; XU, Xiaodong; BLOCK, Timothy, M.
Patent: WO2013/52613 A1, 2013 ;
Location in patent: Paragraph 0140; 0141 ;