2-甲酰基-3,4-二氢吡喃合成路线 （共 35 条）
反应条件
aluminum isopropoxide
参考文献
Shell Devel. Co.
Patent: US2562849 , 1949 ;
反应条件
sodium hydroxide; ethanol; silver nitrate
参考文献
Scherlin et al.
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 22,29
Chem. Zentralbl., 1939 , vol. 110, # I p. 1971
参考文献
Schulz; Wagner
Angewandte Chemie, 1950 , vol. 62, p. 105,111
反应条件
1: 1) NaH, DMSO / 1) 25 deg C, 15 min., DMSO; 2) 25 deg C, 1 h 2: 95 percent / triisobutylaluminium / 1,2-dichloro-ethane / 2 h / 60 °C View Scheme
参考文献
Takai; Mori; Oshima; Nozaki
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 2 p. 446 - 451
反应条件
water; toluene-4-sulfonic acid anschliessende Hydrierung an Raney-Nickel bei pH 5;
参考文献
Shell Devel.Co.
Patent: US2639297 , 1946 ;
反应条件
1: 1) NaH, DMSO / 1) 25 deg C, 15 min., DMSO; 2) 25 deg C, 1 h 2: 61 percent / Et2AlCl, PPh3 / CH2Cl2 / 1 h / 25 °C View Scheme
参考文献
Takai; Mori; Oshima; Nozaki
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 2 p. 446 - 451
反应条件
1: Raney nickel / Hydrogenation 2: pyridine; thionyl chloride View Scheme
参考文献
Crombie et al.
Journal of the Chemical Society, 1956 , p. 136,141
反应条件
1: tetrahydrofuran / -50 - 0 °C
2: 40 percent / PDC, NaOAc, 4 A molecular sieves / CH2Cl2 / 5.5 h / 20 °C
View Scheme
参考文献
Copp, Richard R.; Mundy, Bradford P.
Synthetic Communications, 1989 , vol. 19, # 16 p. 2851 - 2858
反应条件
1: 93 percent / LiAlH4 / diethyl ether / 1 h / 15 °C
2: 52 percent / diethyl ether / 64 h / -20 - -15 °C
3: 1.) 35percent H2O2, conc. H2SO4, 2.) triethylamine, acetic anhydride / 1.) THF, 20 deg C, 24 h, 2.) 20 deg C, 2 h
View Scheme
参考文献
Fehr, Charles; Galindo, Jose; Ohloff, Guenther
Helvetica Chimica Acta, 1981 , vol. 64, # 5 p. 1247 - 1256
反应条件
1: 1.) butyllithium / 1.) diethyl ether, 20-30 min; 2.) 30 min
2: PCC / CH2Cl2 / 1 h
3: triethylamine / 12 h / Ambient temperature
4: 0.2 g / pyridine / 2 h / Ambient temperature
5: 0.1 g / NaIO4, 0.5percent OsO4 / dioxane; H2O / 3.5 h
View Scheme
参考文献
Pirillo, Demetrio; Gazzaniga, Andrea; Traverso, Giorgio
Journal of Chemical Research, Miniprint, 1983 , # 1 p. 133 - 146
