1.1: acetic acid; pyridine / toluene / 24 h / 110 °C / |Reflux; |Inert atmosphere; |Dean-Stark; |Large scale
2.1: 5 palladium on charcoal; hydrogen / methanol / 4 h / 20 °C / 900.09 Torr / |Large scale
3.1: potassium carbonate / acetone; N,N-dimethyl-formamide / 20 h / 60 °C / |Reflux; |Large scale
4.1: sodium methylate / methanol / 10 - 40 °C / |Large scale
4.2: 2.5 h / 10 - 15 °C / |Large scale
5.1: zinc / acetic acid / 20 h / 40 - 45 °C / |Large scale
6.1: hydrogen; palladium 10 on activated carbon / methanol / 96 h / 20 °C / 900.09 Torr / |Large scale
View Scheme
参考文献
Humphrey, Cara E.; Furegati, Markus; Laumen, Kurt; Vecchia, Luigi La; Leuten, Thomas; Constanze D Mueller-Hartwieg; Voegtle, Markus
Organic Process Research and Development, 2007 , vol. 11, # 6 p. 1069 - 1075
