反应条件
1: K2CO3 / xylene / 24 h / 145 °C
2: 1.) Mg / 1.) THF, 2.) THF, 24 h
3: 81 percent / toluene-4-sulphonic acid / ethanol / 24 h / Heating
4: 1.) KOH, 2.) H2, H2SO4 / 2.) 10percent Pd/C / 1.) ethanol, 1 h, reflux, 2.) ethanol, r.t.
5: 4.31 g / PBr3 / CHCl3 / 4 h / 0 °C
6: 1.) LiNH2, Fe(NO3)3 / 1.) liq. NH3, THF, HMPA, 2.) liq. NH3, THF, HMPA, 40 deg C, 24 h
7: p-TsOH / ethanol / 3 h / Heating
8: 0.1704 g / PBr3 / CHCl3 / 16 h / -30 deg C to r. t.
9: 1.) EtMgBr, CuCl / 1.) THF, 1 h, 2.) THF, 72 h, 35 deg C
10: 50 percent / H2, quinoline / 5 percent Pd-BaSO4 / ethyl acetate / 2 h / Ambient temperature
View Scheme
参考文献
Caplin, Joseph; Tyman, John H. P.
Journal of Chemical Research, Miniprint, 1982 , # 2 p. 321 - 351
