1: bis-diphenylphosphine With copper(l) iodide; N-methyl-2-(methylamino)ethylamine in toluene T=20°C; 0.5 h; Inert atmosphere; 2: 1-(2-bromonaphthalen-1-yl)isoquinoline With caesium carbonate in toluene T=20 - 100°C; Buchwald reaction; Inert atmosphere;

1: Pd[P(o-tol)3]2; N-ethyl-N,N-diisopropylamine; (S,S)-iPr-DUPHOS / 1,4-dioxane; toluene / 100 °C / |Glovebox; |Inert atmosphere 2: 1,3,5-trimethyl-benzene / 150 °C View Scheme

1: bis-diphenylphosphine With copper(l) iodide; N-methyl-2-(methylamino)ethylamine in toluene T=20°C; 0.5 h; Inert atmosphere; 2: 1-(2-bromonaphthalen-1-yl)isoquinoline With caesium carbonate in toluene T=20 - 100°C; Buchwald reaction; Inert atmosphere;

1: Pd[P(o-tol)3]2; N-ethyl-N,N-diisopropylamine; (S,S)-iPr-DUPHOS / 1,4-dioxane; toluene / 100 °C / |Glovebox; |Inert atmosphere 2: 1,3,5-trimethyl-benzene / 150 °C View Scheme

1: bis-diphenylphosphine With copper(l) iodide; N-methyl-2-(methylamino)ethylamine in toluene T=20°C; 0.5 h; Inert atmosphere; 2: 1-(2-bromonaphthalen-1-yl)isoquinoline With caesium carbonate in toluene T=20 - 100°C; Buchwald reaction; Inert atmosphere;

1: Pd[P(o-tol)3]2; N-ethyl-N,N-diisopropylamine; (S,S)-iPr-DUPHOS / 1,4-dioxane; toluene / 100 °C / |Glovebox; |Inert atmosphere 2: 1,3,5-trimethyl-benzene / 150 °C View Scheme