1.1: HCl / ethyl acetate; H2O / 0.5 h 1.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C 2.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C 3.1: HCl / ethyl acetate; H2O / 0.5 h 3.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C 4.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9 View Scheme

Multi-step reaction with 2 steps 1.1: HCl / ethyl acetate; H2O / 0.5 h1.2: 81 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C2.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C