1-(叔丁氧基羰基)-4,4-二氟吡咯烷-2-羧酸合成路线 （共 3 条）
反应条件
1: With lithium hydroxide; water in acetonitrile T=25°C; 16 h; 2: With hydrogenchloride in water; acetonitrile
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2007/150001 A1, 2007 ;
Location in patent: Page/Page column 99-100 ;
反应条件
1.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere 2.1: water; lithium hydroxide hydrate / methanol / 2.5 h / 20 °C 2.2: pH 3 View Scheme
参考文献
HEFFERNAN, Michele, L., R.; HARDY, Larry, Wendell; WU, Frank, Xinhe; SARASWAT, Lakshmi, D.; SPEAR, Kerry, L.
Patent: WO2012/170845 A2, 2012 ;
WO 2012/170845 A2
反应条件
1.1: potassium carbonate / acetone / 2 h / Reflux 2.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere 3.1: water; lithium hydroxide hydrate / methanol / 2.5 h / 20 °C 3.2: pH 3 View Scheme
参考文献
HEFFERNAN, Michele, L., R.; HARDY, Larry, Wendell; WU, Frank, Xinhe; SARASWAT, Lakshmi, D.; SPEAR, Kerry, L.
Patent: WO2012/170845 A2, 2012 ;
WO 2012/170845 A2
