hydrogen; palladium on activated carbon in methanol; water T=55°C; 16 h; Product distribution / selectivity;

1.1: hydrogen / palladium 10 on activated carbon / ethanol; water; tetrahydrofuran / 43 h / 50 °C / 2844.39 Torr / Industry scale 2.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale 3.1: diethyl ether; isobutyramide / 1 h / 25 °C 4.1: sodium hydroxide; water / 1.5 h / 100 °C 4.2: 0 °C / pH 1 - 2 View Scheme

Multi-step reaction with 3 steps 1: hydrogen / palladium 10 on activated carbon / ethanol; water; tetrahydrofuran / 43 h / 50 °C / 2844.39 Torr / Industry scale2: pyridine / dichloromethane / 0 - 23 °C / Industry scale3: diethyl ether; isobutyramide / 1 h / 25 °C  

Multi-step reaction with 3 steps 1: hydrogen / palladium 10 on activated carbon / ethanol; water; tetrahydrofuran / 43 h / 50 °C / 2844.39 Torr / Industry scale2: pyridine / dichloromethane / 0 - 23 °C / Industry scale3: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale