3-溴-6-甲基-7-氮杂吲哚合成路线 （共 5 条）
反应条件
N-bromosuccinmide; sulfuric acid in tetrahydrofuran T=20°C; 2 h;
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
Location in patent: Page/Page column 146 ;
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / |Inert atmosphere 1.2: 2 h / 20 °C 2.1: sodium hydroxide; methanol / 4 h / 20 °C 3.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol dimethyl ether / 2 h / 120 °C / |Microwave irradiation 4.1: N-bromosuccinmide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
反应条件
1: sodium hydroxide; methanol / 4 h / 20 °C 2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol dimethyl ether / 2 h / 120 °C / |Microwave irradiation 3: N-bromosuccinmide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
反应条件
1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol dimethyl ether / 2 h / 120 °C / |Microwave irradiation 2: N-bromosuccinmide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / ethylene glycol dimethyl ether / 2 h / 20 °C / |Cooling with ice 2.1: lithium hexamethyldisilazane / tetrahydrofuran / |Inert atmosphere 2.2: 2 h / 20 °C 3.1: sodium hydroxide; methanol / 4 h / 20 °C 4.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol dimethyl ether / 2 h / 120 °C / |Microwave irradiation 5.1: N-bromosuccinmide; sulfuric acid / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
ALMIRALL, S.A.; VIDAL JUAN, Bernat; ALONSO DIEZ, Juan Antonio; BUIL ALBERO, Maria Antonia; EASTWOOD, Paul Robert; ESTEVE TRIAS, Cristina; LOZOYA TORIBIO, Maria Estrella; ROBERTS, Richard Spurring; VIDAL GISPERT, Laura; GONZALEZ RODRIGUEZ, Jacob; MIR CEPEDA, Marta
Patent: WO2013/10880 A1, 2013 ;
