3,4-二-溴-7-氮杂吲哚合成路线 （共 2 条）
反应条件
N-bromosuccinmide in dichloromethane T=0°C; 1.5 h;
参考文献
GLAXO WELLCOME MANUFACTURING PTE LTD; CHEN, Deborah, W.; DUNCAN, Sarah; KING, Nigel, Paul; LEE, Kiew, Ching; MAK, Sing, Yeung; RIVERS, Dean, Andrews
Patent: WO2012/170752 A1, 2012 ;
Location in patent: Page/Page column 29 ;
WO 2012/170752 A1
反应条件
1: With [14C]-Tetramethylammonium bromide; trifluoromethanesulfonic anhydride in N,N-dimethyl-formamide T=0°C; 12 h; Heating; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=7; 0.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/126675 A1, 2009 ;
Location in patent: Page/Page column 128-129 ;
WO 2009/126675 A1
