4-溴-1H-吡咯并[2,3-b]吡啶-3-甲醛合成路线 （共 2 条）
反应条件
propionic acid T=120°C; Reflux;
参考文献
WYETH LLC; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek Suhayl; TSOU, Hwei-Ru; ZHANG, Nan; VENKATESAN, Aranapakam M.; DI, Li; KERNS, Edward H.
Patent: WO2010/30727 A1, 2010 ;
Location in patent: Page/Page column 120 ;
WO 2010/030727 A1
反应条件
1: 4-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; 2: methyl iodide in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C;
参考文献
WYETH LLC; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek Suhayl; TSOU, Hwei-Ru; ZHANG, Nan; VENKATESAN, Aranapakam M.; DI, Li; KERNS, Edward H.
Patent: WO2010/30727 A1, 2010 ;
Location in patent: Page/Page column 120-121 ;
WO 2010/030727 A1
