3-溴-4-氯-7-氮杂吲哚合成路线 （共 2 条）
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 180 ;
WO 2008/005457 A2
反应条件
1: 3-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 25°C; 2 h; 3: With water; ammonium chloride more than 3 stages;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/12635 A2, 2008 ;
Location in patent: Page/Page column 90 ;
