2-甲基-3-氨基-5-溴苯甲酸甲酯合成路线 （共 6 条）
反应条件
iron; ammonium chloride in ethanol; water T=90°C; 1 h;
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
Location in patent: Page/Page column 312 ;
WO 2012/118812 A2
反应条件
1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C 2: ammonium chloride; iron / ethanol; water / 1 h / 90 °C View Scheme
参考文献
WO2012/118812 A2, ;
WO 2012/118812 A2
WO2012/142513 A1, ;
WO 2012/142513 A1
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid / 5 h / 20 °C 2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C 3: ammonium chloride; iron / ethanol; water / 1 h / 90 °C View Scheme
参考文献
WO2012/118812 A2, ;
WO 2012/118812 A2
反应条件
1: nitric acid; sulfuric acid / acetone / 2.25 h / -5 - 0 °C / Cooling with acetone-ice 2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C 3: ammonium chloride; iron / ethanol; water / 7 h / 80 °C View Scheme
参考文献
US2012/264734 A1, ;
US 20120264734 A1
反应条件
1.1: potassium acetate / chloroform / 12 h / 20 °C 1.2: 3 h / 65 °C 2.1: hydrogenchloride / water; methanol / 8 h / 60 °C 2.2: pH 8 View Scheme
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
WO 2012/118812 A2
反应条件
1: With potassium acetate in chloroform T=20°C; 12 h; 2: With tert.-butylnitrite; 18-crown-6 ether in chloroform T=65°C; 3 h;
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
Location in patent: Page/Page column 312-313 ;
WO 2012/118812 A2
