1: With copper(ll) bromide in acetonitrile T=20°C; 1 h; 2: With ammonium hydroxide in methanol; acetonitrile T=20°C; 0.5 h;

1.1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 2.1: hydrogenchloride / methanol / 21 h / 75 °C 3.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation 4.1: copper(ll) bromide / acetonitrile / 1 h / 20 °C 4.2: 0.5 h / 20 °C View Scheme

1.1: hydrogenchloride / methanol / 21 h / 75 °C 2.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation 3.1: copper(ll) bromide / acetonitrile / 1 h / 20 °C 3.2: 0.5 h / 20 °C View Scheme

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation 2.1: copper(ll) bromide / acetonitrile / 1 h / 20 °C 2.2: 0.5 h / 20 °C View Scheme

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 16 h / 20 °C 2.1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 24 h / 65 °C / |Inert atmosphere 3.1: hydrogenchloride / methanol / 21 h / 75 °C 4.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol diethyl ether / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation 5.1: copper(ll) bromide / acetonitrile / 1 h / 20 °C 5.2: 0.5 h / 20 °C View Scheme