1: With chloro-trimethyl-silane; sodium iodide in acetonitrile T=20°C; 2 h; 2: With sodium thiosulfate in water; acetonitrile 3: With sodium hydroxide in water; acetonitrile pH=9; diastereoselective reaction;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '8128150', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />1&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: pyridine / 6 h / 20 &deg;C<br />2: dichloromethane / 3 h / -40 &deg;C<br />3: water; sodium hydrogencarbonate / methanol / 3 h<br />4: pyridine / dichloromethane / -30 &deg;C<br />5: sodium azide / N,N-dimethyl-formamide / 3 h / 60 &deg;C<br />6: sodium hydroxide / methanol; water / 1 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: dichloromethane / 3 h / -40 &deg;C<br />2: water; sodium hydrogencarbonate / methanol / 3 h<br />3: pyridine / dichloromethane / -30 &deg;C<br />4: sodium azide / N,N-dimethyl-formamide / 3 h / 60 &deg;C<br />5: sodium hydroxide / methanol; water / 1 h<br /> <br /> &nbsp;