1000793-42-9合成路线 （共 12 条）
反应条件
caesium carbonate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in acetonitrile T=85°C; 16 h; Inert atmosphere;
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
Location in patent: Page/Page column 293 ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=120°C; 0.333333 h; Microwave irradiation;
参考文献
UCB PHARMA S.A.
Patent: WO2009/71888 A1, 2009 ;
Location in patent: Page/Page column 73-74 ;
WO 2009/071888 A1
反应条件
palladium diacetate in acetonitrile
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
Location in patent: Page/Page column ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=120°C; 0.333333 h; Microwave irradiation;
参考文献
UCB PHARMA S.A.
Patent: WO2008/1076 A1, 2008 ;
Location in patent: Page/Page column 184 ;
WO 2008/001076 A1
反应条件
1.1: ammonia / ethanol / 16 h / -70 - 45 °C / 10343.2 Torr / Autoclave 1.2: 0.5 h / 0 °C / pH 2 / Inert atmosphere 2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3.1: sodium ethanolate / toluene / 4 h / 80 °C 4.1: acetonitrile; water / 3 h / Reflux 5.1: bromine / tetrahydrofuran / 0.17 h / 20 °C 5.2: 2 h / 80 °C 6.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 7.1: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
1.1: bromine / tetrahydrofuran / 0.17 h / 20 °C 1.2: 2 h / 80 °C 2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 3.1: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
1.1: sodium ethanolate / toluene / 4 h / 80 °C 2.1: acetonitrile; water / 3 h / Reflux 3.1: bromine / tetrahydrofuran / 0.17 h / 20 °C 3.2: 2 h / 80 °C 4.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 5.1: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
1.1: acetonitrile; water / 3 h / Reflux 2.1: bromine / tetrahydrofuran / 0.17 h / 20 °C 2.2: 2 h / 80 °C 3.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 4.1: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 2: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 2.1: sodium ethanolate / toluene / 4 h / 80 °C 3.1: acetonitrile; water / 3 h / Reflux 4.1: bromine / tetrahydrofuran / 0.17 h / 20 °C 4.2: 2 h / 80 °C 5.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 6.1: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
