1-(环丙基甲基)-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑合成路线 （共 2 条）
反应条件
1: 2-(1H-Pyrazole-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide 2: bromomethyl-cyclopropane in tetrahydrofuran; N,N-dimethyl-formamide T=20 - 60°C; 16.8 h;
参考文献
INCYTE CORPORATION; ZHANG, Colin; QIAN, Ding-quan; ZHUO, Jincong; YAO, Wenqing
Patent: WO2010/75270 A1, 2010 ;
Location in patent: Page/Page column 158 ;
WO 2010/075270 A1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 12 h; Inert atmosphereSealed tube;
参考文献
ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu
Patent: WO2013/53983 A1, 2013 ;
Location in patent: Page/Page column 33; 34 ;
