2-[(1E)-2-(2-溴-5-氯苯基)乙烯基]苯酚乙酸酯合成路线 (共 2 条)
反应条件
1: 1-bromo-2-(bromomethyl)-4-chlorobenzene With triethyl phosphite T=115°C; 2 h; 2: salicylaldehyde With potassium tert-butylate in tetrahydrofuran T=-10°C; Wittig Reaction; 2 h; 3: acetic anhydride in tetrahydrofuran T=-10°C; 0.25 h;
参考文献
N.V. Organon
Patent: US2008/9619 A1, 2008 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: C11H15BrClO3P; salicylaldehyde With potassium tert-butylate in tetrahydrofuran T=-10°C; Wittig-Horner reaction; 2 h; 2: acetic anhydride in tetrahydrofuran 0.25 h;
参考文献
WO2008/3460 A1, ;
Page/Page column 17-18 ;