3-甲基-5-三氟甲基吡唑合成路线 （共 18 条）
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=20°C; 2: With sodium hydroxide in tetrahydrofuran; water T=20°C;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2007/14290 A2, 2007 ;
Location in patent: Page/Page column 55-56 ;
反应条件
potassium tert-butylate in tetrahydrofuran T=20°C; 1.75 h;
参考文献
MERCK SHARP and DOHME CORP.; RAGHAVAN, Subharekha; STELMACH, John; GUO, Jian; GROEPER, Jonathan; BROCKUNIER, Linda; ROSAUER, Keith; SHEN, Hong; LIANG, Rui; DING, Fa-Xiang; SCHMIDT, Darby
Patent: WO2011/119518 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
反应条件
N-chloro-succinimide in DMF (N,N-dimethyl-formamide) T=70°C; 22 h;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2003/105853 A1, 2003 ;
Location in patent: Page 64 ;
WO 03/105853 A1
反应条件
1: 99 percent / N-bromosuccinimide / dimethylformamide / 1 h / 25 °C 2: 79 percent / K2CO3 / acetone / 1.5 h / 25 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 128, # 10 p. 1191 - 1197
反应条件
bromine; sodium acetate; acetic acid T=0 - 20°C; 21.1667 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/141020 A1, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/141020 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2008/91594 A2, 2008 ;
Location in patent: Page/Page column 72 ;
反应条件
ammonium cerium (IV) nitrate; iodine in acetonitrile
T=20°C;
参考文献
PHARMARESOURCES (SHANGHAI) CO., LTD.; CHEN, Ping; ZHOU, Ding; SHAO, Shaoping; CAI, Zhen-wei
Patent: WO2013/6792 A1, 2013 ;
Location in patent: Paragraph 0151 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2008/91580 A2, 2008 ;
Location in patent: Page/Page column 53 ;
