3-甲基-9H-咔唑-1,4-二酮合成路线 （共 40 条）
反应条件
1: 81 percent / aq HCl / methanol / 4 h / Heating
2: 84 percent / Fremy's salt, KH2PO4 / H2O; acetone / 0.17 h / Ambient temperature
View Scheme
参考文献
Matsuo; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1325 - 1327
反应条件
1: 89 percent / Et3N / CHCl3 / 1 h / Ambient temperature
2: 82 percent / AlCl3, anisole / 0.17 h / 0 °C
3: 81 percent / aq HCl / methanol / 4 h / Heating
4: 84 percent / Fremy's salt, KH2PO4 / H2O; acetone / 0.17 h / Ambient temperature
View Scheme
参考文献
Matsuo; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1325 - 1327
反应条件
1: 82 percent / AlCl3, anisole / 0.17 h / 0 °C
2: 81 percent / aq HCl / methanol / 4 h / Heating
3: 84 percent / Fremy's salt, KH2PO4 / H2O; acetone / 0.17 h / Ambient temperature
View Scheme
参考文献
Matsuo; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1325 - 1327
反应条件
1: 49 percent / 30percent H2O2aq., AcOH / tetrahydrofuran / 1 h / -2 - 0 °C
2: 89 percent / Et3N / CHCl3 / 1 h / Ambient temperature
3: 82 percent / AlCl3, anisole / 0.17 h / 0 °C
4: 81 percent / aq HCl / methanol / 4 h / Heating
5: 84 percent / Fremy's salt, KH2PO4 / H2O; acetone / 0.17 h / Ambient temperature
View Scheme
参考文献
Matsuo; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1325 - 1327
反应条件
1: 59 percent / <bis(trifluoroacetoxy)iodo>benzene
2: 93 percent / HCl / methanol
View Scheme
参考文献
Wada; Hirai; Hanaoka
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 2 p. 416 - 418
反应条件
1: manganese(IV) oxide / dichloromethane / 48 h / Reflux
2: Grubb's 2nd generation catalyst / toluene / 1 h / 70 °C
3: hydrogenchloride; water / methanol / 1 h / 60 °C
View Scheme
参考文献
Nishiyama, Takashi; Choshi, Tominari; Kitano, Kohdai; Hibino, Satoshi
Tetrahedron Letters, 2011 , vol. 52, # 30 p. 3876 - 3878
反应条件
1: tetrahydrofuran / 4 h / 0 °C
2: manganese(IV) oxide / dichloromethane / 48 h / Reflux
3: Grubb's 2nd generation catalyst / toluene / 1 h / 70 °C
4: hydrogenchloride; water / methanol / 1 h / 60 °C
View Scheme
参考文献
Nishiyama, Takashi; Choshi, Tominari; Kitano, Kohdai; Hibino, Satoshi
Tetrahedron Letters, 2011 , vol. 52, # 30 p. 3876 - 3878
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 24 h / 70 °C
2: tetrahydrofuran / 4 h / 0 °C
3: manganese(IV) oxide / dichloromethane / 48 h / Reflux
4: Grubb's 2nd generation catalyst / toluene / 1 h / 70 °C
5: hydrogenchloride; water / methanol / 1 h / 60 °C
View Scheme
参考文献
Nishiyama, Takashi; Choshi, Tominari; Kitano, Kohdai; Hibino, Satoshi
Tetrahedron Letters, 2011 , vol. 52, # 30 p. 3876 - 3878
反应条件
1: toluene-4-sulfonic acid / methanol / 5 h / 20 °C / Inert atmosphere
2: sodium cyanoborohydride / methanol / 2 h / 20 °C / Inert atmosphere
3: [bis(acetoxy)iodo]benzene; acetic acid; trifluoroacetic acid / methanol; water / 1 h / 50 °C / Inert atmosphere
View Scheme
参考文献
Bhosale, Shrikar M.; Momin, Aadil A.; Kusurkar, Radhika S.
Tetrahedron, 2012 , vol. 68, # 32 p. 6420 - 6426
反应条件
1: 89 percent / DDQ / dioxane / 1 h / Heating
2: 60 percent / TfOH / trifluoroacetic acid / 0.25 h / Heating
View Scheme
参考文献
Murphy, William S.; Bertrand, Martial
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 24 p. 4115 - 4119
