5-溴-3-甲酰基-1H-吲哚-2-羧酸乙酯合成路线 （共 6 条）
反应条件
1: N,N-dimethyl-formamide With oxalyl dichloride in dichloromethane T=0°C; 0.333333 h; 2: 5-bromo-1H-indole-2-carboxylic acid ethyl ester in dichloromethane; N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
BIOLIPOX AB
Patent: WO2006/77367 A1, 2006 ;
Location in patent: Page/Page column 89 ;
WO 2006/077367 A1
反应条件
trichlorophosphate in 1,2-dichloro-ethane Vilsmeier-Haack reaction; Heating;
参考文献
Hickman; Sturino; Lachance
Tetrahedron Letters, 2000 , vol. 41, # 43 p. 8217 - 8220
反应条件
1: polyphosphoric acid 2: POCl3; 1,2-dichloro-ethane / Behandeln des Reaktionsgemisches mit wss. Natriumacetat View Scheme
参考文献
Cavallini et al.
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 113,114
反应条件
2: polyphosphoric acid 3: POCl3; 1,2-dichloro-ethane / Behandeln des Reaktionsgemisches mit wss. Natriumacetat View Scheme
参考文献
Cavallini et al.
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 113,114
反应条件
1: aq.-ethanolic KOH 2: N,N-dimethylaniline / Erhitzen des erhaltenen Reaktionsgemisches mit Wasser. View Scheme
参考文献
Cavallini et al.
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 113,114
反应条件
1: With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid in dichloromethane T=10°C; Baeyer-Villiger oxidation; 2: With dimethylsulfide; ethanol
参考文献
Hickman; Sturino; Lachance
Tetrahedron Letters, 2000 , vol. 41, # 43 p. 8217 - 8220
