sodium hydrogencarbonate in ethyl acetate T=0°C; Acylation; 0.333333 h;

1: 80 percent / DMSO; (COCl)2; Et3N / CH2Cl2 / 0.75 h / -78 - 20 °C 2: 70 percent / 4 Angstroem molecular sieves; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C View Scheme

potassium tert-butylate in tert-butyl alcohol T=20 - 30°C; 3.5 h;