S-1-Boc-4，4-二甲基吡咯烷-2-甲酸合成路线 （共 6 条）
反应条件
lithium hydroxide in tetrahydrofuran; methanol; water T=20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
Location in patent: Page/Page column 71 ;
US 20080009497 A1
反应条件
water; lithium hydroxide hydrate in ethanol T=0 - 20°C; 6 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; HEWAWASAM, Piyasena
Patent: WO2012/39717 A1, 2012 ;
Location in patent: Page/Page column 153 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 20 °C 3: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C View Scheme
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
US 20080009497 A1
反应条件
2: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C View Scheme
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
US 20080009497 A1
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 20 °C 3: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C View Scheme
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
US 20080009497 A1
反应条件
1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2: water; lithium hydroxide hydrate / ethanol / 6 h / 0 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; HEWAWASAM, Piyasena
Patent: WO2012/39717 A1, 2012 ;
