4-(溴甲基)噻唑-2-氨基甲酸叔丁酯合成路线 （共 5 条）
反应条件
phosphorus tribromide in dichloromethane T=0 - 20°C;
参考文献
GLAXO GROUP LIMITED; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Mallo-Rubio, Araceli
Patent: US2013/203802 A1, 2013 ;
Location in patent: Paragraph 0248; 0249 ;
反应条件
in acetone T=20°C; Hantzsch Thiazole Synthesis; 24 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 41 ;
US 20080009465 A1
反应条件
lithium bromide in dichloromethane; acetone T=20°C; 1 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9465 A1, 2008 ;
Location in patent: Page/Page column 41 ;
US 20080009465 A1
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C 2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.42 h / 0 °C 2.2: 1 h / 20 °C View Scheme
参考文献
GLAXO GROUP LIMITED; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Mallo-Rubio, Araceli
Patent: US2013/203802 A1, 2013 ;
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 16 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C 3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.42 h / 0 °C 3.2: 1 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MENG, Wei; CHENG, Peter T. W.
Patent: WO2011/130459 A1, 2011 ;
WO 2011/130459 A1
