(5-(羟基甲基)噻唑-2-基)氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
lithium triethylborohydride in tetrahydrofuran T=-45 - 20°C; 23 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
Location in patent: Page/Page column 68 ;
WO 2011/059839 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h; 2: With sodium hydroxide; water in tetrahydrofuran 0.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MENG, Wei; CHENG, Peter T. W.
Patent: WO2011/130459 A1, 2011 ;
Location in patent: Page/Page column 64; 65 ;
WO 2011/130459 A1
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 5.5 h / 30 °C 2: lithium triethylborohydride / tetrahydrofuran / 23 h / -45 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MENG, Wei; CHENG, Peter T. W.
Patent: WO2011/130459 A1, 2011 ;
WO 2011/130459 A1
反应条件
manganese(IV) oxide in dichloromethane; ethyl acetate T=20°C; 14 h;
参考文献
McCormick, Kevin D.; Aslanian, Robert G.; Mangiaracina, Pietro; Berlin, Michael Y.; De Lera Ruiz, Manuel; Boyce, Christopher W.; Chao, Jianhua; Ting, Pauline C.; Zheng, Junying; Rosenblum, Stuart B.
Patent: US2011/166124 A1, 2011 ;
Location in patent: Page/Page column 42 ;
