ammonium hydroxide; copper(l) iodide; (2S,4R)-2-carboxy-4-hydroxypyrrolidine in dimethyl sulfoxide T=80°C;

1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / Reflux 2: copper(l) iodide; ammonium hydroxide; (2S,4R)-2-carboxy-4-hydroxypyrrolidine / dimethyl sulfoxide / 80 °C View Scheme