(R)-(+)-苯乙醇腈合成路线 （共 51 条）
反应条件
hydrogenchloride in ethyl acetate T=27°C;
参考文献
Yang, Wen-Bin; Fang, Jim-Min
Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 1356 - 1359
反应条件
(R)-oxynitrilase (almond meal); citric buffer pH 5.5 in ethyl acetate T=4°C; 48 h; other aldehydes and methyl ketones, also in micro-aqueous phase, var temp. and solvents; Product distribution;
参考文献
Tuekel, S. Seyhan; Yildirim, Deniz; Alagoez, Dilek; Alptekin, Oezlem; Yuecebilgi, Guezide; Bilgin, Ramazan
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 161 - 165
反应条件
4 A molecular sieve; dimethylaluminum chloride; triphenyl-phosphine oxide; (S)-3,3'-bis[(diethylamino)methyl]-2,2'-dihydroxy-1,1'-binaphthalene in toluene T=-20°C; Strecker reaction; 6 h;
参考文献
Casas, Jesus; Najera, Carmen; Sansano, Jose M.; Saa, Jose M.
Organic Letters, 2002 , vol. 4, # 15 p. 2589 - 2592
反应条件
in di-isopropyl ether; water T=25°C; 240 h; (S)-oxynitrilase; Title compound not separated from byproducts;
参考文献
Kiljunen; Kanerva
Tetrahedron Asymmetry, 1994 , vol. 5, # 3 p. 311 - 314
反应条件
titanium tetraethoxide; N-((2-hydroxy-1-naphthyl)methylene)-(S)-valyl-(S)-tryptophan methyl ester in toluene T=-60°C; 16 h; other aldehydes; other dipeptide (or amino acids amides or esters) aldimine-deriv. - titanium alkoxide complexes as catalysts; var. temp. and reaction times; Mechanism;
参考文献
Journal of the American Chemical Society, , vol. 114, # 21 p. 7969 - 7975
反应条件
titanium(IV) isopropylate; (S)-valinol; 3-tert-butyl-2-hydroxybenzaldehyde in dichloromethane T=-80°C; 24 h; enantioselective trimethylsilylcyanation, var. Schiff's bases, var. cond., other aldehydes;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 24 p. 1752 - 1753
反应条件
1: benzaldehyde With (1R,2R)-cyclohexane-1,2-diylbis(2-azaethenyl-3-tert-butyl-2-hydroxybenzo-5-sulfonic acid) disodium salt; Manganese (II) acetate in methanol T=20°C; 0.5 h; 2: sodium cyanide in methanol T=20°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Qu, Yanyang; Jing, Linhai; Wu, Zhiqing; Wu, Di; Zhou, Xiangge
Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 187 - 190
反应条件
Candida antarctica Lipase type B in toluene T=80°C; 8 h; Microwave irradiationResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ribeiro, Sandra S.; De Oliveira, Julieta R.; Porto, Andre L. M.
Journal of the Brazilian Chemical Society, 2012 , vol. 23, # 7 p. 1395 - 1399
反应条件
R-selective hydroxynitrile lyase from Prunus amygdalus in various solvent(s) T=20°C; pH=3.3; 3 h;
参考文献
Tetrahedron, , vol. 60, # 3 p. 735 - 739
反应条件
toluene-4-sulfonic acid in 1,4-dioxane; water 16 h; Heating;
参考文献
Elliott, John D.; Choi, Vanessa M. F.; Johnson, William S.
Journal of Organic Chemistry, 1983 , vol. 48, # 13 p. 2294 - 2295
