(R)-(+)-苯乙醇腈合成路线 （共 51 条）
反应条件
Prunus armeniaca from Himalayan plum in water; dimethyl sulfoxide pH=4; 0.0833333 h; citrate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Synlett, , # 8 p. 1237 - 1240
反应条件
sodium citrate buffer (pH=5,45) in water; ethyl acetate T=5°C; 48 h; almond meal paste (oxynihilase);
参考文献
Van Den Nieuwendijk; Warmerdam; Brussee; Van Der Gen
Tetrahedron Asymmetry, 1995 , vol. 6, # 3 p. 801 - 806
反应条件
hydrogenchloride in dichloromethane T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 57, # 5 p. 805 - 814
反应条件
1: 1.) titanium tetrachloride / 1.) dichloromethane, -78 deg C, 25 min, 2.) -78 deg C, 45 min 2: 98 percent / pyridinium dichromate / CH2Cl2 / 18 h / 25 °C 3: 93 percent / 0.6percent p-TSOH*H2O / dioxane; H2O / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 13 p. 2294 - 2295
反应条件
1: 98 percent / pyridinium dichromate / CH2Cl2 / 18 h / 25 °C 2: 93 percent / 0.6percent p-TSOH*H2O / dioxane; H2O / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 48, # 13 p. 2294 - 2295
反应条件
1: With dimethylsulfide borane complex; (S)-3,3-diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol in tetrahydrofuran; dichloromethane; toluene T=0°C; 2: With hydrogenchloride in tetrahydrofuran; methanol; dichloromethane; water; toluene 0.5 h; optical yield given as percent ee;
参考文献
Letters in Organic Chemistry, , vol. 6, # 8 p. 637 - 641
反应条件
1: With Prunus amygdalus hydroxynitrile lyase in tert-butyl methyl ether T=0°C; 1.5 h; aq. bufferEnzymatic reaction; 2: With hydrogenchloride in tert-butyl methyl ether; water enantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 10 p. 3461 - 3464
反应条件
quinidine in di-isopropyl ether T=40°C; 39 h; lipase from Pseudomonas sp. M-12-13; Yield given. Yields of byproduct given;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 65, # 1 p. 111 - 120
反应条件
1: 74 percent / pyridine / diethyl ether / 12 h / Ambient temperature 2: aq. NaOAc, HOAc / 7 h / Ambient temperature; Pseudomonas fluorescens lipase, pH 4.5 View Scheme
参考文献
Liebigs Annalen der Chemie, , # 1 p. 47 - 54
反应条件
M. esculenta enzyme preparation immobilized on alginate gel in diethyl ether T=45°C; Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 12 p. 1418 - 1423
