(R)-(+)-苯乙醇腈合成路线 （共 51 条）
反应条件
hydrogenchloride; borane-THF 1a) THF, reflux, 1 h 1b) r.t., 12 h; Yield given. Multistep reaction;
参考文献
Tanaka, Kenzo; Mori, Atsunori; Inoue, Shohei
Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 181 - 185
反应条件
1.1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 6 h / 0 - 20 °C 2.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / |Inert atmosphere 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C 3.2: 1 h / 20 °C 4.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C 4.2: 3.5 h / 0 °C 5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 6.1: water; tetrahydrofuran / 3 h / 65 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C 8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C View Scheme
参考文献
Rej, Rohan Kalyan; Das, Tapas; Hazra, Suman; Nanda, Samik
Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 913 - 918
反应条件
hydrogenchloride in diethyl ether T=4°C; 12 h;
参考文献
Tanaka, Kenzo; Mori, Atsunori; Inoue, Shohei
Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 181 - 185
反应条件
phosphate buffer 1.) Rhodococcus botanica ATCC 21197, 30 deg C, 48 h; Yield given. Multistep reaction;
参考文献
Kakeya, Hideaki; Sakai, Naoko; Sugai, Takeshi; Ohta, Hiromichi
Agricultural and Biological Chemistry, 1991 , vol. 55, # 7 p. 1877 - 1881
反应条件
1: pyridine / diethyl ether 2: 3.) NaBH4 View Scheme
参考文献
Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G.
Australian Journal of Chemistry, 1990 , vol. 43, # 12 p. 2045 - 2062
反应条件
Amberlite IRA904 OH(1-) in toluene T=60°C; 0.75 h; Product distribution; Further Variations:Temperatures;
参考文献
Li, Yu-Xin; Straathof, Adrie J.J.; Hanefeld, Ulf
Tetrahedron Asymmetry, 2002 , vol. 13, # 7 p. 739 - 743
反应条件
1: 90 percent / CF3COOH / CH2Cl2 / Ambient temperature 2: 2.) 10percent citric acid / 1.) a.) ether, reflux, 1 h, b.) RT, overnight, 2.) 2 h 3: 2 M H2SO4 / CHCl3 / Ambient temperature View Scheme
参考文献
Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G.
Australian Journal of Chemistry, 1990 , vol. 43, # 12 p. 2045 - 2062
反应条件
1: 90 percent / CF3COOH / CH2Cl2 / Ambient temperature 2: 2.) 10percent citric acid / 1.) a.) ether, reflux, 1 h, b.) RT, overnight, 2.) 2 h 3: 2 M H2SO4 / CHCl3 / Ambient temperature View Scheme
参考文献
Jackson, W. Roy; Jacobs, Howard A.; Jayatilake, Gamini S.; Matthews, Barry R.; Watson, Keith G.
Australian Journal of Chemistry, 1990 , vol. 43, # 12 p. 2045 - 2062
反应条件
lithium aluminium tetrahydride in diethyl ether 3 h; Ambient temperature;
参考文献
Ziegler, Thomas; Hoersch, Brigitte; Effenberger, Franz
Synthesis, 1990 , # 7 p. 575 - 578
反应条件
1.1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 6 h / 0 - 20 °C 2.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / |Inert atmosphere 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C 3.2: 1 h / 20 °C 4.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C 4.2: 3.5 h / 0 °C 5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 6.1: water; tetrahydrofuran / 3 h / 65 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Rej, Rohan Kalyan; Das, Tapas; Hazra, Suman; Nanda, Samik
Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 913 - 918
