2-(溴甲基)-6-氟吡啶合成路线 (共 2 条)
反应条件
N-bromosuccinmide; 1,1'-azobis (cyclohexanecarbonitrile) in tetrachloromethane 18 h; UV-irradiation;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/2181 A2, 2007 ;
Location in patent: Page/Page column 148-149 ;
WO 2007/002181 A2
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane Inert atmosphereReflux;
参考文献
Kuang, Gui-Chao; Michaels, Heather A.; Simmons, J. Tyler; Clark, Ronald J.; Zhu, Lei
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6540 - 6548