1: 2-chloro-5-fluoro-N-(4-((2-(methylthio)pyrimidin-4-ylamino)methyl)benzyl)pyrimidin-4-amine With 3-chloro-benzenecarboperoxoic acid in dichloromethane T=0°C; 2: 2-(N-morpholino)ethylamine With N-ethyl-N,N-diisopropylamine in 1,4-dioxane T=95°C; 18 h;

1.1: thionyl chloride / methanol / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 3.2: 18 h / 95 °C View Scheme

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 2.2: 18 h / 95 °C View Scheme

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 60 °C 2.1: thionyl chloride / methanol / 0 - 20 °C 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 4.2: 18 h / 95 °C View Scheme