3-乙氧基羰基亚甲基-氮杂丁烷-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
sodium hydride in tetrahydrofuran Horner-Wadsworth-Emmons olefination; 20 h;
参考文献
Collier, Philip N.
Tetrahedron Letters, 2009 , vol. 50, # 27 p. 3909 - 3911
反应条件
1: 3-oxo-azetidine-1-carboxylic acid tert-butyl ester With sodium hydride in tetrahydrofuran T=0°C; 2: triethyl phosphonoacetate in tetrahydrofuran T=20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; BURGESS, Laurence E.; EARY, C. Todd; GRONEBERG, Robert; HACHE, Bruno P.; HARVEY, Darren; HICKEN, Erik James; KRASER, Christopher F.; LAIRD, Ellen; MORENO, David A.; MUNSON, Mark C.; REN, Li; ROBINSON, John E.; SCHLACHTER, Stephen T.
Patent: WO2013/55645 A1, 2013 ;
Location in patent: Paragraph 00404 ;
反应条件
in dichloromethane Wittig Olefination; 6 h; Inert atmosphereSchlenk techniqueReflux;
参考文献
Li, Dong Bo; Rogers-Evans, Mark; Carreira, Erick M.
Organic Letters, 2013 , vol. 15, # 18 p. 4766 - 4769
